Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) affects 5–8% of reproductive-age women. The morbidity related to PCOS may include insulin-resistance, type 2 diabetes mellitus (T2DM), obesity, hypertension, cardiovascular disease and infertility. We aimed to evaluate the clinico-biochemical characteristics of PCOS women and establish its relationship with fertility treatment outcomes.Methods: We reviewed clinical records of PCOS women (Rotterdam crite...

Introduction: The deleterious effects of obesity on spontaneous reproduction are well recognized, although the literature on obesity and assisted reproductive technology outcome remains heterogeneous and inconsistent.Objective: To estimate the effect of BMI on ovarian stimulation response and live birth in women underwent in vitro fertilization (IVF).Methods: Retrospective observational study that included women submitted ...

Introduction: Several studies recommend the use of molecular tests for a complete diagnosis of malignancy in thyroid carcinomas (TC). The study and identification of molecular markers in thyroid will contribute to a personalized and effective treatment of the patients. The development of TC has been associated with the activation of oncogenes that are implicated in the cell signaling pathway, interfering in cancer promotion and outcome. Moreover, the repertoire of microRNAs (m...

Introduction: Monogenic forms of diabetes that develop with autosomal dominant inheritance are classically aggregated in the maturity-onset diabetes of the young (MODY) categories. Despite increasing awareness, its true prevalence remains largely underestimated.Aim: o evaluate the clinical and molecular characteristics of patients with MODY.Methodology: This single-center retrospective cohort study enrolled patients with positive g...

Introdution: Erdheim-Chester disease is a rare multisystemic form of Non-langerhans cell histiocytosis CD67 positive, with approximately 550 published cases. Papillary carcinoma is the most common thyroid cancer with BRAF V600E the most common mutation. Both diseases may be associated to BRAF V600E mutation. If Erdheim- Chester disease is positive to this mutation on histiocytes, a specific pharmacolgical treatment is available, (vemurafenib), with better results.<p class=...